Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease
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چکیده
منابع مشابه
Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.
In Alzheimer's disease (AD), the pathological accumulation of tau appears to be a downstream effect of amyloid β protein (Aβ). However, the relationship between these two proteins and memory loss is unclear. In this study, we evaluated the specific removal of pathological tau oligomers in aged Tg2576 mice by passive immunotherapy using tau oligomer-specific monoclonal antibody. Removal of tau o...
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C l i n M e d International Library Citation: Rohn TT (2015) Caspase Cleaved Tau in Alzheimer’s Disease: A Therapeutic Target Realized. Int J Neurol Neurother 1:014. doi.org/10.23937/2378-3001/2/1/1014 Received: January 06, 2015: Accepted: January 09, 2015: Published: January 12, 2015 Copyright: © 2015 Rohn TT. This is an open-access article distributed under the terms of the Creative Commons A...
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Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identification. Previously we proposed ligand polarizability, a measure of electron delocalization, as a candi...
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The relationship of the neurofibrillary tangle, found in Alzheimer disease and aged brains, to normal or abnormal cytoskeletal proteins remains elusive. Although immunohistochemical studies have yielded disparate results, most antigenic determinants localized to neurofibrillary tangles are cytoskeletal constituents normally present in neuronal perikarya or dendrites. We report light and electro...
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Abnormal aggregation of tau protein within the cytoplasm of susceptible neurons has been considered one of the major hallmarks that define the neuropathology of Alzheimer’s disease (AD) (Iqbal et al., 2010; Pritchard et al., 2011). At early stages of neuronal degeneration tau protein is accumulated in the form of early non-assembled aggregates that may alter the normal functioning of affected n...
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ژورنال
عنوان ژورنال: Alzheimer's Research & Therapy
سال: 2014
ISSN: 1758-9193
DOI: 10.1186/alzrt277